JPID - Vol 04 - Issue 03

About the Cover

Tissue engineering (TE) is a multi disciplinary approach employing the principles of biology and engineering to produce vital replacements for the lost tissues and vital organs.

Although attempts have been made to engineer almost all types of mammalian tissues, a tissue engineered cartilage, especially fibrocartilaginous structure like temporomandibular disc is still a challenge for researchers.

The three key elements of TE includes a) cell sources, b) scaffolds and c) bio active agents.

Currently, a series of highly potent human stem cells, both embryonic and adult, such as multipotent mesenchymal stem cells (MSCs) (Fig 1), umbilical cord matrix stem cells, and pluripotent embryonic stem cells (ESCs) (Fig 2), have turned up with positive results in TMJ tissue regeneration.

Other than polyglycolic acid (PGA)and Poly-L-Lactic acid (PLLA) nonwoven mesh scaffolds, synthetic polymers like poly(glycerol sebacate) (PGS), polycaprolactone (PCL) (Fig 3) and natural polymers like Chitosan and alginate are presently used as (Ch/Alg) hybrid scaffolds (Fig 4) for cartilage and bone regeneration.

The use of costal chondrocytes enabled the use of scaffold less ‘self assembly’ technique.

To enhance cellular proliferation various growth factors (Fig 5) have been investigated for TMJ disc tissue engineering: platelet-derived growth factor (PDGF); basic fibroblast growth factor (bFGF); transforming growth factor-b1 (TGF-b1); transforming growth factor-b3 (TGF-b3); and insulin-like growth factor-I (IGF-I).

To simulate forces generated during function, a mechanical stimuli may be required to produce an optimally engineered construct. Presentlyit is accomplished by using a rotating wall bioreactor (Fig 6) or by applying a continuous hydrostatic pressure of 10 MPa.

The rapid advancements in the field if bio engineering provides positive signals and a functional and biological replacement for temporomandibular disc (Fig 7) is not far from reality.

Dr Kavitha Manoj
Assistant Professor of Prosthodontics,
Government Dental College, Trivandrum.


Editorial: RESEARCH DESIGNS – An Overview

Article 1: Comparison of strain generated by short and conventional implants supporting distal extension removable partial overdenture– a photo elastic analysis

Poornima K., Shruthi C S., Poojya.R., Shruthy Panicker

Article 2: CAD/CAM and its clinical applications in dentistry

Ponjayanthi V, Femin David, T. Sreelal, T. C. Giri, Aparna Mohan

Article 3: Immediate loading in implant dentistry: a review

Jimmy George, Anoopa Paulose, Jinsa P Devassy, Jacob George

Article 4: Direct post and core patterns with urethane dimethacrylate resin- a clinical technique

Noleen Jacob, Menon Prasad Rajagopal, Subin Eranhikkal, Pradeep Samuel, Sreedevi S., Rahul Nageshraj

Article 5: Metal-free prosthodontics: a review

Twinkle Hatmode, Kalyani Deshmukh, Neelam PandeSaee Deshpande, Usha Radke, Rajlakshmi Banerjee

Article 6: Implants splinted to natural teeth- a review

Syam Kumar S J, Anjali G Pai

Article 7: Awareness, knowledge and attitude of prosthodontists and other dental practitioners towards precision attachments: a survey.

Vidhi Himanshu Sheth, Mrinmayee Tushar Thakur, Naisargi Prashant Shah, Sangeeta Yadav, Vishrut Mohan Bhatnagar, Ashutosh Ramesh Pai

Article 8: Prosthetic rehabilitation of surgically reconstructed mandible with increased crown height space

Vinod Krishnan, Manju V, Apurva Thampi, Kasthuri C, Krishnapriya V N., Arjun Krishnadas, Pramod Subash, Subramania Iyer

Article 9: A comparative evaluation of effectiveness of ozonated water over commercially available denture cleansing tablets on candida species biofilm in heat cured PMMA resin plates.

Anjana V.R, Joyal Jose Baby, Sudeep S.


Haby Mathew Somson

JPID – The journal of Prosthetic and Implant Dentistry / Volume 4 Issue 3 / May–August 2021

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