Dr Prasanth V
Prisma-P and Prospero
Systematic review and meta-analysis (SRMA) are the supreme collective scientific evidence available in our literature. Conducting a SRMA is a time consuming, relatively expensive team work. There are many funding options for a relevant SRMA. Hence it is advisable to check whether our proposed SRMA is unique or whether someone else is currently doing it. One can do it by searching PROSPERO maintained by University of York, Cochrane library, PubMed and Google Scholar.
It is mandatory to register SRMA; PROSPERO is a major registration option. PROSPERO doesn’t allow multiple registrations of the same topic unless a valid justification can be given. PROSPERO requires a registration which is free of coast. Registration can be done by visiting https:// www.crd.york.ac.uk/prospero/ . After login, we can either register our SRMA or we can search ongoing SRMA. Having a protocol as per PRISMA-P guidelines is mandatory for a smooth registration process. Registration increases the credibility of the SRMA and eliminates the chance of unnecessary duplication of the work.
Protocol helps to plan and anticipate problems associated with SRMA. There are different methods for preparing the protocol; Cochrane protocols and PRISMA-P protocols. This editorial will deal with PRISMA-P protocols. Preferred Reporting Items for Systematic review and Meta-Analysis (PRISMA) was published in 2015 ( Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA. Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4(1):1. doi: 10.1186/2046-4053-4-1). PRISMA-P specifically talks about protocols, PRISMA about manuscript writing and PRISMA-S about reporting search strategies.
PRISMA-P statement (http://www.prisma-statement. org/Extensions/Protocols ) contains some very important items. Administrative information includes identification (Title, original or updated SRMA), registration details, author information (primary and contributors), amendments (indicate ONLY if the protocol is a modification of the earlier one) and support (information regarding funding). Introduction includes rationale and objectives. Methods include eligibility criteria (study characters like PICO, study design and setting, time frame etc.), information sources (all intended digital and other sources), search strategy (MESH terms, Boolean operators, synonyms etc.), study records (data management methods like Rayyan, selection process like who screens the data and data collection process like MS excel / spread sheet), data (define al variables), role of bias in individual studies (describe methods for assessing risk of bias at study level or outcome level or both), data synthesis (describe the statistical aspects), meta bias (publication bias among studies, possibility of selective reporting) and confidence in cumulative evidence.